As long as coach Zinedine Zidane chooses him within the match-day squad, there is no reason Pepe won't be able to play if called upon on against Real Betis on Sunday night at 20:45CET.
After a gym session alongside Fabio Coentrao on Thursday, the Portuguese defender will join Friday's training with the rest of his teammates.
Nonetheless, Nacho is expected to start alongside Sergio Ramos on Sunday night given Zidane's rotation policy in LaLiga.
