With five shots on target, Lazio cruised to a 5-0 early lead against a helpless Palermo within the opening half hour, with ex-Barcelona youth product Balde Keita netting a hat-trick in just six minutes.
Ciro Imobile opened the scoring in the 8th minute and quickly grabbed a brace a minute later, virtually ending the match before it even really got started as relegation zone Palermo could never handle Europa League Lazio.
Andrea Rispoli added a second half brace of his own, but a comeback was never really on the cards, with Luca Crecco putting the icing on the cake with a late goal to take Lazio's tally to six.
Keita's hat-trick is the fastest in Serie A history, breaking Andriy Shevchenko's previous record of seven minutes back in 2000 against Perugia.